Transfer Hydrogenation and Transfer Hydrogenolysis. XVIII

Asymmetric Hydrogenation and Transfer Hydrogenation of Ketones

Optically active alcohols are important building blocks in the synthesis of fine chemicals, pharmaceuticals, agrochemicals, flavors and fragrances as well as functional materials (Arai & Ohkuma, 2011; Klingler, 2007). Furthermore, molecular hydrogen is without doubt the cleanest reducing agent, with complete atom efficiency. Therefore, the catalytic, asymmetric hydrogenation (AH) of prochiral k...

Ruthenium Catalyzed Transfer Hydrogenation

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Chemoselectivity in Transfer-Hydrogenation Reactions

Organocatalytic transfer hydrogenation of cyclic enones.

The first enantioselective organocatalytic transfer hydrogenation of cyclic enones has been accomplished. The use of iminium catalysis has provided a new organocatalytic strategy for the enantioselective reduction of beta,beta-substituted alpha,beta-unsaturated cycloalkenones, to generate beta-stereogenic cyclic ketones. The use of imidazolidinone 4 as the asymmetric catalyst has been found to ...

Organocatalytic asymmetric transfer hydrogenation of imines